Image of intestines with a cropped circle showing a close up view of microrganisms in the microbiome. There is also another cropped circle with a magnifying glass examining data. TrialNet logo is in the top left corner.
Research Spotlight
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Exploring the fascinating connection between the gut microbiome and immune therapy
While conducting research in his lab at Yale University, TrialNet Chair Kevan Herold, MD, discovered an interesting outcome. Mouse models (mice genetically modified to mimic a human condition) treated with multiple antibiotics did not respond to the immune therapy teplizumab, the only FDA-approved treatment to delay the onset of type 1 diabetes (T1D).
