Image of intestines with a cropped circle showing a close up view of microrganisms in the microbiome. There is also another cropped circle with a magnifying glass examining data. TrialNet logo is in the top left corner.
Research Spotlight

Exploring the fascinating connection between the gut microbiome and immune therapy

While conducting research in his lab at Yale University, TrialNet Chair Kevan Herold, MD, discovered an interesting outcome. Mouse models (mice genetically modified to mimic a human condition) treated with multiple antibiotics did not respond to the immune therapy teplizumab, the only FDA-approved treatment to delay the onset of type 1 diabetes (T1D). 

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4 poloroid photos of maisie on a blue and pink background. Maisie celebrates wearing a pump and cgm in the first photos. The last photos feature Maisie's Diabetes Link chapter and a Diabuddy stuffed animal.
Participant Spotlight

Meet Maisie Mische: Turning a T1D diagnosis into opportunities

When Maisie Mische, a 22-year-old mechanical engineering student at Marquette University, started having trouble with her vision last year, she attributed the problem to eye fatigue from late-night studying. But two episodes of double vision and subsequent tests revealed something more complex: type 1 diabetes (T1D).

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red blue and green graphic. Text reads "reflecting on 2024" and features artwork from the TOPPLE Study, T1D RELAY Study, and JAKPOT T1D study positioned on a timeline
Media Release

Reflecting on 2024 with TrialNet Chair Kevan Herold, MD

As we begin a new year, it’s the perfect time to celebrate our accomplishments. We recently spoke with TrialNet Chair Kevan Herold, MD, to get his insights on the past year and plans for the year ahead. Dr. Herold is a professor of immunobiology and medicine at Yale University, one of 17 TrialNet Clinical Centers at the forefront of type 1 diabetes research.

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The Tremblay family (Laura, 2nd from right; Bella, far left).
Participant Spotlight

Meet Laura Tremblay: Former screening skeptic turned advocate

The Tremblay family (Laura, 2nd from right; Bella, far left).

Laura Tremblay’s type 1 diabetes (T1D) journey began in 2018, when her 9-year-old daughter, Bella, was admitted to the hospital in diabetic ketoacidosis (DKA). Like many families without a history of T1D, the Tremblays didn’t recognize the symptoms.

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Headshots of researchers involved in the BANDIT trial in new onset diabetes
Research Spotlight

Groundbreaking study finds JAK inhibitor baricitinib slows type 1 diabetes progression

World-first study findings by Australian researchers show a daily pill containing the JAK inhibitor baricitinib can preserve insulin production in people newly diagnosed with T1D. Published in the December issue of the New England Journal of Medicine, findings were co-authored by Thomas Kay, MBBS, PhD,  and Helen Thomas, PhD, St.

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