SickKids building

The Hospital for Sick Children (SickKids) is one of twenty-five type 1 diabetes TrialNet International Clinical Centres at the forefront of type 1 diabetes research. Led by Diane Wherrett, MD, the TrialNet team at SickKids is dedicated to preventing type 1 diabetes and stopping disease progression by preserving insulin production before and after diagnosis. 

Our Team

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Diane Wherrett, MD

Diane received her medical degree at Queen's University in Kingston, Ontario.  She trained in Paediatrics and Paediatric Endocrinology at The Hospital for Sick Children, Toronto and did a research fellowship in the immunology of type 1 diabetes at Stanford University. She is currently a Staff Physician in the Division of Endocrinology, Department of Paediatrics, Associate Professor at the University of Toronto and Program Director, Paediatric Endocrinology Training Program at The Hospital for Sick Children. She is the Canadian Centre Director for Type 1 Diabetes TrialNet.

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Lesley Eisel

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Roze Kovalakovska

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Mary-Jo Ricci

“TrialNet is important to me because it allows families such as mine to play an active role in the fight against type 1 diabetes”--Samantha De Lima, SickKids

Regional Affiliates

University of British Columbia
4480 Oak Street , Vancouver, V6H 3V4 Canada
Stollery Children's Hospital - Alberta Health Services
Edmonton Clinic Health Academy (ECHA), 11405-87 Avenue , Edmonton, T6G 1C9 Canada
University of Manitoba
510-715 McDermot Ave. , Winnipeg, R3E 2P4 Canada
Childrens Hospital of Eastern Ontario
401 Smyth Road Room R250G, Ottawa, K1H8L1 Canada
IWK Health Center
5850/5980 University Ave , Halifax, B3K 6R8 Canada
The Janeway Child Health and Rehabilitation Centre
300 Prince Phillip Dr. , St. John's, A1B 3V6 Canada
Hamilton Health Sciences
1200 Main St W, 2G Clinics - 2G49 , Hamilton, L8N 3Z5 Canada
Alberta Childrens Hospital
2888 Shaganappi Trail NW , Calgary, T3B 6A8 Canada
University of Western Ontario
339 Windermere Road, Rm. 60F11 , London, N6A5A5 Canada
Royal University Hospital
103 Hospital Drive , Saskatoon, S7N 0W8 Canada

“I have been a T1D researcher for over 18 years and I am passionate about TrialNet’s mission to prevent children from getting new onset diabetes.”--Dina Panagiotopolous, MD, University of British Columbia

Research Studies

Risk Screening Risk Screening

If you have a relative with T1D, you may be eligible for risk screening that can detect the early stages of T1D years before symptoms appear. More

Monitoring Monitoring

Depending on your risk screening results, you may be eligible for monitoring. We’ll monitor you for disease progression and let you know if you become eligible for a study. More

Prevention Study Abatacept Prevention Study

TrialNet is testing the drug abatacept to see if it can delay or prevent progression of early stage T1D (stage 1 or stage 2), and ultimately prevent clinical diagnosis (stage 3). In earlier studies for people newly diagnosed (stage 3), abatacept helped slow down disease progression. Details

Prevention Study Hydroxychloroquine (HCQ)

We are testing the drug hydroxychloroquine (HCQ) to see if it can delay or prevent early stage T1D (stage 1) from progressing to abnormal glucose tolerance (stage 2) and ultimately prevent clinical diagnosis (stage 3). HCQ is already used to reduce symptoms and progression of other autoimmune diseases, such as rheumatoid arthritis and lupus. This is the first study to see if it can prevent or delay T1D. Details

Long Term Longterm Follow-up

If you are diagnosed with T1D while participating in one of our prevention studies, we’re still here for you. You can continue to receive personal monitoring while helping us learn more. More

“I am a TrialNet Coordinator because curing type 1 Diabetes is my retirement plan”--Claire Gougeon, Alberta Children's Hospital

#T1DFamily Spotlight

Meet some of our TrialNet #T1DFamily members to learn what it’s like to participate in a TrialNet clinical research study.